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ps80  (Spectrum Chemicals Inc)

 
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    Structured Review

    Spectrum Chemicals Inc ps80
    Observed particle dissolution profiles into phosphate buffer (pH 6.8) with and without surfactant. Panels A, B, and C are for posaconazole, ritonavir, and griseofulvin, respectively. Dissolution involved 5 mg of drug powder in 100ml. Five different media were no surfactant, 2 % SLS, 2 % <t>PS80,</t> 2 % POE10, and 2 % CTAB. Surfactant markedly increased posaconazole, ritonavir, and griseofulvin dissolution.
    Ps80, supplied by Spectrum Chemicals Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/ps80/ps80/pmc12776685-99-0-4
    Average 86 stars, based on 1 article reviews
    ps80 - by Bioz Stars, 2026-09
    86/100 stars

    Images

    1) Product Images from "Prediction of surfactant-mediated dissolution of poorly soluble drugs from drug powder"

    Article Title: Prediction of surfactant-mediated dissolution of poorly soluble drugs from drug powder

    Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

    doi: 10.1016/j.ejps.2025.107052

    Observed particle dissolution profiles into phosphate buffer (pH 6.8) with and without surfactant. Panels A, B, and C are for posaconazole, ritonavir, and griseofulvin, respectively. Dissolution involved 5 mg of drug powder in 100ml. Five different media were no surfactant, 2 % SLS, 2 % PS80, 2 % POE10, and 2 % CTAB. Surfactant markedly increased posaconazole, ritonavir, and griseofulvin dissolution.
    Figure Legend Snippet: Observed particle dissolution profiles into phosphate buffer (pH 6.8) with and without surfactant. Panels A, B, and C are for posaconazole, ritonavir, and griseofulvin, respectively. Dissolution involved 5 mg of drug powder in 100ml. Five different media were no surfactant, 2 % SLS, 2 % PS80, 2 % POE10, and 2 % CTAB. Surfactant markedly increased posaconazole, ritonavir, and griseofulvin dissolution.

    Techniques Used: Dissolution

    Sensitivity analysis results for h fixed . In comparing predicted and observed profiles, root mean square error (RMSE) is plotted as a function of fixed diffusion layer thickness. Media was no surfactant, 2 % SLS, 2 % PS80, 2 % POE10, and 2 % CTAB, respectively. Panels A-E are for posaconazole. Panels F-J are for ritonavir. Panels K-O are for griseofulvin.
    Figure Legend Snippet: Sensitivity analysis results for h fixed . In comparing predicted and observed profiles, root mean square error (RMSE) is plotted as a function of fixed diffusion layer thickness. Media was no surfactant, 2 % SLS, 2 % PS80, 2 % POE10, and 2 % CTAB, respectively. Panels A-E are for posaconazole. Panels F-J are for ritonavir. Panels K-O are for griseofulvin.

    Techniques Used: Diffusion-based Assay

    Sensitivity analysis results for h max . In comparing predicted and observed profiles, RMSE is plotted as a function of maximum diffusion layer thickness. Media was no surfactant, 2 % SLS, 2 % PS80, 2 % POE10, and 2 % CTAB, respectively. Panels A-E are for posaconazole. Panels F-J are for ritonavir. Panels K-O are for griseofulvin.
    Figure Legend Snippet: Sensitivity analysis results for h max . In comparing predicted and observed profiles, RMSE is plotted as a function of maximum diffusion layer thickness. Media was no surfactant, 2 % SLS, 2 % PS80, 2 % POE10, and 2 % CTAB, respectively. Panels A-E are for posaconazole. Panels F-J are for ritonavir. Panels K-O are for griseofulvin.

    Techniques Used: Diffusion-based Assay

    Predicted particle dissolution profiles of posaconazole with and without surfactant using h fixed = 12μm. Panels A, B, C, D, and E are for no surfactant, 2 % SLS, 2 % PS80, 2 % POE10, and 2 % CTAB, respectively. Dissolution involved 5 mg of API in 100 ml. One predicted profile considered the entire particle size distribution (denoted entire PSD) in . The other predicted profile assumed a monodisperse powder with a particle size equal to the mean size [i.e., D 50 =10 μm (denoted mean only)]. Also shown is observed profile. All predicted profiles were within 20 % dissolved of observed profile at 30 min and 60 min.
    Figure Legend Snippet: Predicted particle dissolution profiles of posaconazole with and without surfactant using h fixed = 12μm. Panels A, B, C, D, and E are for no surfactant, 2 % SLS, 2 % PS80, 2 % POE10, and 2 % CTAB, respectively. Dissolution involved 5 mg of API in 100 ml. One predicted profile considered the entire particle size distribution (denoted entire PSD) in . The other predicted profile assumed a monodisperse powder with a particle size equal to the mean size [i.e., D 50 =10 μm (denoted mean only)]. Also shown is observed profile. All predicted profiles were within 20 % dissolved of observed profile at 30 min and 60 min.

    Techniques Used: Dissolution

    Predicted particle dissolution profiles of ritonavir with and without surfactant using h fixed = 12μm. Panels A, B, C, D, and E are for no surfactant, 2 % SLS, 2 % PS80, 2 % POE10, and 2 % CTAB, respectively. Dissolution involved 5 mg of API in 100ml. One predicted profile considered the entire particle size distribution (denoted entire PSD) in . The other predicted profile assumed a monodisperse powder with a particle size equal to the mean size [i.e., D 50 = 3 μm (denoted mean only)]. Also shown is observed profile. All predicted profiles were within 20 % dissolved of observed profile at 30 min and 60 min using entire PSD. Predicted profile was over-predicted for dissolution at 60 min into 2 % PS80 using mean only, but otherwise accurate using mean only.
    Figure Legend Snippet: Predicted particle dissolution profiles of ritonavir with and without surfactant using h fixed = 12μm. Panels A, B, C, D, and E are for no surfactant, 2 % SLS, 2 % PS80, 2 % POE10, and 2 % CTAB, respectively. Dissolution involved 5 mg of API in 100ml. One predicted profile considered the entire particle size distribution (denoted entire PSD) in . The other predicted profile assumed a monodisperse powder with a particle size equal to the mean size [i.e., D 50 = 3 μm (denoted mean only)]. Also shown is observed profile. All predicted profiles were within 20 % dissolved of observed profile at 30 min and 60 min using entire PSD. Predicted profile was over-predicted for dissolution at 60 min into 2 % PS80 using mean only, but otherwise accurate using mean only.

    Techniques Used: Dissolution

    Predicted particle dissolution profiles of griseofulvin with and without surfactant using h fixed = 12μm. A, B, C, D, and E are for no surfactant, 2 % SLS, 2 % PS80, 2 % POE10, and 2 % CTAB, respectively. Dissolution involved 5 mg of API in 100 ml. One predicted profile considered the entire particle size distribution (denoted entire PSD) in . The other predicted profile assumed a monodisperse powder with a particle size equal to the mean size [i.e., D 50 = 9 μm (denoted mean only)]. Also shown is observed profile. All predicted profiles were within 20 % dissolved of observed profile at 30 min and 60 min using entire PSD. Predicted profile was over-predicted for dissolution at 30 min into 2 % CTAB using mean only, but otherwise accurate using mean only.
    Figure Legend Snippet: Predicted particle dissolution profiles of griseofulvin with and without surfactant using h fixed = 12μm. A, B, C, D, and E are for no surfactant, 2 % SLS, 2 % PS80, 2 % POE10, and 2 % CTAB, respectively. Dissolution involved 5 mg of API in 100 ml. One predicted profile considered the entire particle size distribution (denoted entire PSD) in . The other predicted profile assumed a monodisperse powder with a particle size equal to the mean size [i.e., D 50 = 9 μm (denoted mean only)]. Also shown is observed profile. All predicted profiles were within 20 % dissolved of observed profile at 30 min and 60 min using entire PSD. Predicted profile was over-predicted for dissolution at 30 min into 2 % CTAB using mean only, but otherwise accurate using mean only.

    Techniques Used: Dissolution

    Related Articles

    other:

    Article Title: Prediction of surfactant-mediated dissolution of poorly soluble drugs from drug powder
    Article Snippet: PS80 was purchased from Spectrum Chemicals (New Brunswick, NJ).

    Article Title: Prediction of surfactant-mediated dissolution of poorly soluble drugs from drug powder.
    Article Snippet: PS80 was purchased from Spectrum Chemicals (New Brunswick, NJ).

    Concentration Assay:

    Article Title: Polysorbate 80 Inhibition of Pseudomonas aeruginosa Biofilm Formation and Its Cleavage by the Secreted Lipase LipA
    Article Snippet: .. PS80 (Spectrum Chemicals, Gardena, CA) was prepared as a 1% solution in double-distilled water (water is referred to as vehicle in the rest of the text) and was used at a concentration of 0.01%, unless otherwise noted. .. Oleic acid (Fluka/ Sigma, St. Louis, MO) was prepared as a 10% solution in 95% ethanol.



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    Image Search Results


    PS80-coated DNA is much less sensible to ionic strength changes than the bare biopolymer, suggesting that the effective interactions between the surfactant and the double helix (hydrophobic coating, volume exclusion effect, etc.) reduce the effective exposure of the phosphate backbone to the surrounding ionic environment, as illustrated.

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    Article Title: Interactions Involving Neutral Surfactants and Double-Stranded DNA: The Case of Polysorbate 80 (Tween 80)

    doi: 10.1021/acsomega.5c11135

    Figure Lengend Snippet: PS80-coated DNA is much less sensible to ionic strength changes than the bare biopolymer, suggesting that the effective interactions between the surfactant and the double helix (hydrophobic coating, volume exclusion effect, etc.) reduce the effective exposure of the phosphate backbone to the surrounding ionic environment, as illustrated.

    Article Snippet: Such a result indicates that the PS80-coated DNA is much less sensible to ionic strengths changes than the bare biopolymer, suggesting that the effective interactions between the surfactant and the double-helix (hydrophobic coating, volume exclusion effect, etc.) reduces ionic sensitivity.

    Techniques:

    Observed particle dissolution profiles into phosphate buffer (pH 6.8) with and without surfactant. Panels A, B, and C are for posaconazole, ritonavir, and griseofulvin, respectively. Dissolution involved 5 mg of drug powder in 100ml. Five different media were no surfactant, 2 % SLS, 2 % PS80, 2 % POE10, and 2 % CTAB. Surfactant markedly increased posaconazole, ritonavir, and griseofulvin dissolution.

    Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

    Article Title: Prediction of surfactant-mediated dissolution of poorly soluble drugs from drug powder

    doi: 10.1016/j.ejps.2025.107052

    Figure Lengend Snippet: Observed particle dissolution profiles into phosphate buffer (pH 6.8) with and without surfactant. Panels A, B, and C are for posaconazole, ritonavir, and griseofulvin, respectively. Dissolution involved 5 mg of drug powder in 100ml. Five different media were no surfactant, 2 % SLS, 2 % PS80, 2 % POE10, and 2 % CTAB. Surfactant markedly increased posaconazole, ritonavir, and griseofulvin dissolution.

    Article Snippet: PS80 was purchased from Spectrum Chemicals (New Brunswick, NJ).

    Techniques: Dissolution

    Sensitivity analysis results for h fixed . In comparing predicted and observed profiles, root mean square error (RMSE) is plotted as a function of fixed diffusion layer thickness. Media was no surfactant, 2 % SLS, 2 % PS80, 2 % POE10, and 2 % CTAB, respectively. Panels A-E are for posaconazole. Panels F-J are for ritonavir. Panels K-O are for griseofulvin.

    Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

    Article Title: Prediction of surfactant-mediated dissolution of poorly soluble drugs from drug powder

    doi: 10.1016/j.ejps.2025.107052

    Figure Lengend Snippet: Sensitivity analysis results for h fixed . In comparing predicted and observed profiles, root mean square error (RMSE) is plotted as a function of fixed diffusion layer thickness. Media was no surfactant, 2 % SLS, 2 % PS80, 2 % POE10, and 2 % CTAB, respectively. Panels A-E are for posaconazole. Panels F-J are for ritonavir. Panels K-O are for griseofulvin.

    Article Snippet: PS80 was purchased from Spectrum Chemicals (New Brunswick, NJ).

    Techniques: Diffusion-based Assay

    Sensitivity analysis results for h max . In comparing predicted and observed profiles, RMSE is plotted as a function of maximum diffusion layer thickness. Media was no surfactant, 2 % SLS, 2 % PS80, 2 % POE10, and 2 % CTAB, respectively. Panels A-E are for posaconazole. Panels F-J are for ritonavir. Panels K-O are for griseofulvin.

    Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

    Article Title: Prediction of surfactant-mediated dissolution of poorly soluble drugs from drug powder

    doi: 10.1016/j.ejps.2025.107052

    Figure Lengend Snippet: Sensitivity analysis results for h max . In comparing predicted and observed profiles, RMSE is plotted as a function of maximum diffusion layer thickness. Media was no surfactant, 2 % SLS, 2 % PS80, 2 % POE10, and 2 % CTAB, respectively. Panels A-E are for posaconazole. Panels F-J are for ritonavir. Panels K-O are for griseofulvin.

    Article Snippet: PS80 was purchased from Spectrum Chemicals (New Brunswick, NJ).

    Techniques: Diffusion-based Assay

    Predicted particle dissolution profiles of posaconazole with and without surfactant using h fixed = 12μm. Panels A, B, C, D, and E are for no surfactant, 2 % SLS, 2 % PS80, 2 % POE10, and 2 % CTAB, respectively. Dissolution involved 5 mg of API in 100 ml. One predicted profile considered the entire particle size distribution (denoted entire PSD) in . The other predicted profile assumed a monodisperse powder with a particle size equal to the mean size [i.e., D 50 =10 μm (denoted mean only)]. Also shown is observed profile. All predicted profiles were within 20 % dissolved of observed profile at 30 min and 60 min.

    Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

    Article Title: Prediction of surfactant-mediated dissolution of poorly soluble drugs from drug powder

    doi: 10.1016/j.ejps.2025.107052

    Figure Lengend Snippet: Predicted particle dissolution profiles of posaconazole with and without surfactant using h fixed = 12μm. Panels A, B, C, D, and E are for no surfactant, 2 % SLS, 2 % PS80, 2 % POE10, and 2 % CTAB, respectively. Dissolution involved 5 mg of API in 100 ml. One predicted profile considered the entire particle size distribution (denoted entire PSD) in . The other predicted profile assumed a monodisperse powder with a particle size equal to the mean size [i.e., D 50 =10 μm (denoted mean only)]. Also shown is observed profile. All predicted profiles were within 20 % dissolved of observed profile at 30 min and 60 min.

    Article Snippet: PS80 was purchased from Spectrum Chemicals (New Brunswick, NJ).

    Techniques: Dissolution

    Predicted particle dissolution profiles of ritonavir with and without surfactant using h fixed = 12μm. Panels A, B, C, D, and E are for no surfactant, 2 % SLS, 2 % PS80, 2 % POE10, and 2 % CTAB, respectively. Dissolution involved 5 mg of API in 100ml. One predicted profile considered the entire particle size distribution (denoted entire PSD) in . The other predicted profile assumed a monodisperse powder with a particle size equal to the mean size [i.e., D 50 = 3 μm (denoted mean only)]. Also shown is observed profile. All predicted profiles were within 20 % dissolved of observed profile at 30 min and 60 min using entire PSD. Predicted profile was over-predicted for dissolution at 60 min into 2 % PS80 using mean only, but otherwise accurate using mean only.

    Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

    Article Title: Prediction of surfactant-mediated dissolution of poorly soluble drugs from drug powder

    doi: 10.1016/j.ejps.2025.107052

    Figure Lengend Snippet: Predicted particle dissolution profiles of ritonavir with and without surfactant using h fixed = 12μm. Panels A, B, C, D, and E are for no surfactant, 2 % SLS, 2 % PS80, 2 % POE10, and 2 % CTAB, respectively. Dissolution involved 5 mg of API in 100ml. One predicted profile considered the entire particle size distribution (denoted entire PSD) in . The other predicted profile assumed a monodisperse powder with a particle size equal to the mean size [i.e., D 50 = 3 μm (denoted mean only)]. Also shown is observed profile. All predicted profiles were within 20 % dissolved of observed profile at 30 min and 60 min using entire PSD. Predicted profile was over-predicted for dissolution at 60 min into 2 % PS80 using mean only, but otherwise accurate using mean only.

    Article Snippet: PS80 was purchased from Spectrum Chemicals (New Brunswick, NJ).

    Techniques: Dissolution

    Predicted particle dissolution profiles of griseofulvin with and without surfactant using h fixed = 12μm. A, B, C, D, and E are for no surfactant, 2 % SLS, 2 % PS80, 2 % POE10, and 2 % CTAB, respectively. Dissolution involved 5 mg of API in 100 ml. One predicted profile considered the entire particle size distribution (denoted entire PSD) in . The other predicted profile assumed a monodisperse powder with a particle size equal to the mean size [i.e., D 50 = 9 μm (denoted mean only)]. Also shown is observed profile. All predicted profiles were within 20 % dissolved of observed profile at 30 min and 60 min using entire PSD. Predicted profile was over-predicted for dissolution at 30 min into 2 % CTAB using mean only, but otherwise accurate using mean only.

    Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

    Article Title: Prediction of surfactant-mediated dissolution of poorly soluble drugs from drug powder

    doi: 10.1016/j.ejps.2025.107052

    Figure Lengend Snippet: Predicted particle dissolution profiles of griseofulvin with and without surfactant using h fixed = 12μm. A, B, C, D, and E are for no surfactant, 2 % SLS, 2 % PS80, 2 % POE10, and 2 % CTAB, respectively. Dissolution involved 5 mg of API in 100 ml. One predicted profile considered the entire particle size distribution (denoted entire PSD) in . The other predicted profile assumed a monodisperse powder with a particle size equal to the mean size [i.e., D 50 = 9 μm (denoted mean only)]. Also shown is observed profile. All predicted profiles were within 20 % dissolved of observed profile at 30 min and 60 min using entire PSD. Predicted profile was over-predicted for dissolution at 30 min into 2 % CTAB using mean only, but otherwise accurate using mean only.

    Article Snippet: PS80 was purchased from Spectrum Chemicals (New Brunswick, NJ).

    Techniques: Dissolution